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Columbia State Historic Park

Phone Number

(209) 588-9128

Park Hours

Columbia is a real town, it never actually closes. Most businesses are open from 10:00am to 5:00pm.

Driving Directions to Columbia SHP

Columbia State Historic Park is three miles north of Sonora, off Highway 49.
View on Map

Camping and Lodging

Online reservations are available 24 hours a day, seven days a week. Reservations can be made 6 months in advance via the ReserveCalifornia website, or by calling the toll free telephone number at 1-800-444-7275. Click on the Online Reservations link or the banner below that to go directly to our ReserveCalifornia page. If your stay will be in the next 48 hours please call the hotel directly at (209) 532-1479 for availability.

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Upcoming Park Events

No events scheduled at this moment.

Stay with us!
Click here to reserve a room at theCity and Fallon Hotel or one of the historic cottages.
Click here to see our Current Hotel Specials
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Columbia State Historic Park is three miles north of Sonora, off Highway 49.The parks address is 11255 Jackson Street Columbia CA, 95310.Our nonprofit Friends of Columbia sponsors interpretation and education at Columbia State Historic Park.Their mission, goals and events are listed at: Clearance Amazon Aquazzura Xena Cage Sandals Buy Cheap Shop For Sale Prices Cheap Sale Free Shipping Discount Good Selling qMOZCyB
The town's old Gold Rush-era business district has been preserved with shops, restaurants and two hotels. Visitors have the chance to time-travel to the 1850s, imagining life when gold miners rubbed shoulders with businessmen and the other residents in Columbia. Visitors can experience a bygone era watching proprietors in period clothing conduct business in the style of yesterday. There are opportunities to ride a 100 year-old stagecoach, pan for gold, and explore the real working businesses of Columbia.

Climate At an elevation of 2,100 feet in the Sierra Nevada, summer days can be hot and evenings can cool down quickly. Winters are rainy, with snow at times.

Weather Average Annual Rainfall: 40 inchesAverage Daily High Temperatures:Winter: 59 FSummer 89F

Special School programs designed to meet state curriculum standards for 4th graders are offered from September-June.Programs include Town and Schoolhouse Tours, Gold Trek, and Diggins Tent Town EducationDays. Programs are popular and fill quickly. To sign up or learn more information, click Clearance Low Shipping Tory Burch Metallic SlipOn Sneakers Cheap Sale Real Free Shipping Very Cheap Outlet Online O5NjANVj
2018/2019 School Tour Reservation Information

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Shibata, Katsumi; Morita, Nobuya; Kawamura, Tomoyo; Tsuji, Ai; Fukuwatari, Tsutomu

Fatty liver is caused when rats are given orotic acid of the pyrimidine base in large quantities. The lack of B-group vitamins suppresses the biosynthesis of fatty acids. We investigated how orotic acid-induced fatty liver affects the concentrations of liver , blood, and urine B-group vitamins in rats . The vitamin B6 and B12 concentrations of liver , blood, and urine were not affected by orotic acid-induced fatty liver . Vitamin B2 was measured only in the urine, but was unchanged. The liver , blood, and urine concentrations of niacin and its metabolites fell dramatically. Niacin and its metabolites in the liver , blood, and urine were affected as expected. Although the concentrations of vitamin B1, pantothenic acid, folate, and biotin in liver and blood were decreased by orotic acid-induced fatty liver , these urinary excretion amounts showed a specific pattern toward increase. Generally, as for the typical urinary excretion of B-group vitamins, these are excreted when the body is saturated. However, the ability to sustain vitamin B1, pantothenic acid, folate, and biotin decreased in fatty liver , which is hypothesized as a specific phenomenon. This metabolic response might occur to prevent an abnormally increased biosynthesis of fatty acids by orotic acid.

Microarray analysis in rat liver slices correctly predicts in vivo hepatotoxicity.

Elferink, M G L; Olinga, P; Draaisma, A L; Merema, M T; Bauerschmidt, S; Polman, J; Schoonen, W G; Groothuis, G M M

2008-06-15

The microarray technology, developed for the simultaneous analysis of a large number of genes, may be useful for the detection of toxicity in an early stage of the development of new drugs. The effect of different hepatotoxins was analyzed at the gene expression level in the rat liver both in vivo and in vitro. As in vitro model system the precision-cut liver slice model was used, in which all liver cell types are present in their natural architecture. This is important since drug-induced toxicity often is a multi-cellular process involving not only hepatocytes but also other cell types such as Kupffer and stellate cells. As model toxic compounds lipopolysaccharide (LPS, inducing inflammation), paracetamol (necrosis), carbon tetrachloride (CCl(4), fibrosis and necrosis) and gliotoxin (apoptosis) were used. The aim of this study was to validate the rat liver slice system as in vitro model system for drug-induced toxicity studies. The results of the microarray studies show that the in vitro profiles of gene expression cluster per compound and incubation time, and when analyzed in a commercial gene expression database, can predict the toxicity and pathology observed in vivo. Each toxic compound induces a specific pattern of gene expression changes. In addition, some common genes were up- or down-regulated with all toxic compounds. These data show that the rat liver slice system can be an appropriate tool for the prediction of multi-cellular liver toxicity. The same experiments and analyses are currently performed for the prediction of human specific toxicity using human liver slices.

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