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Grape Juice Concentrate Protects Rat Liver Against Cadmium Intoxication: Histopathology, Cytochrome C and Metalloproteinases Expression.

de Moura, C F G; Ribeiro, F A P; Handan, B A; Aguiar, O; Oshima, C T F; Ribeiro, D A

The aim of this study was to investigate if grape juice concentrate is able to protect rat liver against cadmium toxicity. For this purpose, histopathological analysis, cytochrome C expression and immunoexpresssion of metalloproteinases (MMP) 2 and 9 were investigated. A total of 15 Wistar rats weighing 250 g on the average, and 8 weeks age were distributed into 3 groups (n=5), as follows: Control group (non-treated group, CTRL); Cadmium group (Cd) and grape juice concentrate group (Cd+GJ). Histopathological analysis revealed that liver from animals treated with grape juice concentrate improved tissue degeneration induced by cadmium intoxication. Animals intoxicated with cadmium and treated with grape juice concentrate showed higher cytochrome C gene expression in liver cells. No significant statistically differences (p>0.05) were found to MMP 2 and 9 immunoexpression between groups. Taken together, our results demonstrate that grape juice concentrate is able to prevent tissue degeneration in rat liver as a result of increasing apoptosis. © Georg Thieme Verlag KG Stuttgart · New York.

Biomechanism of chlorogenic acid complex mediated plasma free fatty acid metabolism in rat liver .

H V, Sudeep; K, Venkatakrishna; Patel, Dipak; K, Shyamprasad


Plasma free fatty acids (FFA) are involved in blood lipid metabolism as well as many health complications. The present study was conducted to evaluate the potential role of chlorogenic acid complex from green coffee bean (CGA7) on FFA metabolism in high fat diet fed rats . Hyperlipidemia was induced in Wistar rats using high-fat diet. The animals were given CGA7/orlistat concurrently for 42Âdays. The parameters analysed during the study include plasma and liver total cholesterol (TC), Triglycerides (TG) and FFA. AMPK activation in the liver was analysed through ELISA. The multiple factors involved in AMPK mediated FFA metabolism were analysed using western blotting. CGA7 (50, 100, 150Âmg/kg BW) decreased triglycerides (TG) and FFA levels in plasma and liver . CGA7 administration led to the activation of AMP-activated protein kinase (AMPK) and a subsequent increase in the levels of carnitine palmitoyltransferase 1 (CPT-1). There was a decrease in acetyl-CoA carboxylase (ACC) activity as evident by the increase in its phosphorylation level. Chlorogenic acids improved the blood lipid metabolism in rats by alleviating the levels of FFA and TG, modulating the multiple factors in liver through AMPK pathway. The study concludes that CGA7 complex can be promoted as an active ingredient in nutrition for obesity management.

Effect of low temperature on metabolism of rat liver slices and epididymal fat pads.

Hillyard, L. A.; Entenman, C.

Study of low temperature effects on the metabolism of radioisotope-tagged glucose and palmitate in rat liver slices and epididymal fat pads. The obtained data suggest that the oxidative capacity of rat liver and adipose tissue is maintained at low temperatures to a greater degree than the synthetic capacity. It was concluded that sufficient energy can be produced at 17 C for maintenance of essential tissue functions by these two tissues but that the energy requirements may not be met at 7 C.

Multiformity of elongation factor eEF-2 isolated from rat liver cells.

Gajko, A; Gałasiński, W; Gindzieński, A


Two fractions of eEF-2 (M(r) approx. 100,000 and M(r) approx. 65,000) were isolated from post-ribosomal supernatant of the rat liver cells. Only eEF-2, with mol. weight of about 100,000 Da, can be phosphorylated, but only eEF-2, with mol. weight of about 65,000 Da, was isolated from the active polyribosomes. The existence of two eEF-2 forms with different properties in the rat liver cells is striking and uncovers new aspects for the cellular function of this protein.

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The elongation factor 2 (eEF-2) protein kinase was isolated from rat liver cells, purified and partly characterized. It was found that the enzyme exists in an inactive form in the homogenate of rat liver . The active fraction of kinase eEF-2 was obtained after removal of the inhibitory substance by hydroxyapatite column chromatography. The purified enzyme is an electrophoretically homogeneous protein with relative molecular mass of approximately 90,000 and isoelectric point, pI = 5.9. The enzyme specifically phosphorylates the elongation factor eEF-2 in the presence of calmodulin and Ca2+.

Phosphatase of regenerating liver -3 is expressed in acute lymphoblastic leukemia and mediates leukemic cell adhesion, migration and drug resistance

Hjort, Magnus A.; Abdollahi, Pegah; Vandsemb, Esten N.; Fenstad, Mona H.; Lund, Bendik; Slørdahl, Tobias S.; Børset, Magne; Rø, Torstein B.

Phosphatase of regenerating liver -3 (PRL-3/PTP4A3) is upregulated in multiple cancers, including BCR-ABL1- and ETV6-RUNX-positive acute lymphoblastic leukemia (ALL). With this study, we aim to characterize the biological role of PRL-3 in B cell ALL (B-ALL). Here, we demonstrate that PRL-3 expression at mRNA and protein level was higher in B-ALL cells than in normal cells, as measured by qRT-PCR or flow cytometry. Further, we demonstrate that inhibition of PRL-3 using shRNA or a small molecular inhibitor reduced cell migration towards an SDF-1α gradient in the preB-ALL cell lines Reh and MHH-CALL-4. Knockdown of PRL-3 also reduced cell adhesion towards fibronectin in Reh cells. Mechanistically, PRL-3 mediated SDF-1α stimulated calcium release, and activated focal adhesion kinase (FAK) and Src, important effectors of migration and adhesion. Finally, PRL-3 expression made Reh cells more resistance to cytarabine treatment. In conclusion, the expression level of PRL-3 was higher in B-ALL cells than in normal cells. PRL-3 promoted adhesion, migration and resistance to cytarabine. PRL-3 may represent a novel target in the treatment of B-ALL. PMID:29423065

Prerequisites: None. No prior soldering experience necessary.

Materials: None

Max students: 12

Registration: (Opens July 8, 2018 at 15:00 PDT)

Saturday, 1000-1400 in Icon E

AWS is the most widely used cloud environments today and almost every security professional have to encounter this environment whether you are attacking an organization or defending it. In this fast-paced workshop we will teach participants with some neat tools, techniques and procedures to attack the most widely used AWS services as well as to defend them.- Recon / Information Gathering on AWS Services - Attacking S3 buckets - Exploiting web application flaws to compromise AWS services (IAM/KMS) - Attacking Serverless applications - Disrupting AWS Logging - Attacking Misconfigured Cloud SDN Takeaways: Students will be able to understand and appreciate the delta in attack surface which gets added due to moving to cloud. And subsequently design architecture and develop applications to defend them. What will participants be provided? - PDF copy of slide deck - Lab VM - Workshop lab manual - Bonus labs Target Audience: - Cloud Security Engineers - DevOps engineers - Security Analyst - Penetration Testers - Anyone else who is interested in Cloud Security - If you are an Expert or Advanced user, you may join us as co-trainers! :-)

Prerequisites: - Need to have AWS account (Free-tier) - Basic understanding of AWS

Materials: - Machine with at least 8 GB RAM and 20 GB free HD space - VirtualBox [VMs will be provided]

Registration: (Opens July 8, 2018 at 15:00 PDT)

Vaibhav Gupta Vaibhav is working as a Security Researcher with Adobe Systems. His expertise lies in infusing design and architecture level security in applications hosted in-house and on cloud environments. With ~9 years of diverse InfoSec exposure, he has strong experience in attacking and defending applications including the ones hosted on the cloud. He is co-leading the OWASP and Null community in Delhi region and has delivered multiple sessions at the local and global stage. Vaibhav is also co-organizer for BSides Delhi.

Vaibhav Gupta

Sandeep Singh Sandeep is a Security Managing Consultant with NotSoSecure. He has over 5 years of experience in delivering high end security consulting services to clients across the globe. Sandeep has also worked in Detection and Response teams in the past. He is the co-lead of OWASP Delhi chapter and Community Manager of null community and actively contributes to the local security community. He has conducted and delivered many talks and workshops for the local community in the past. Sandeep is also one of the organizers of BSides Delhi.

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Vice President – Card Payments Systems, TEB, Turkey

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